OncoKB Sensitivity Levels
L1FDA-approved biomarker in this tumor type
L2Standard of care in this tumor type
L3A/3BCompelling or investigational clinical evidence (other tumors)
L4Biological evidence only
OncoKB Resistance Levels
R1Standard of care resistance marker
R2Investigational resistance marker
ClinVar Pathogenicity
Path.Pathogenic — disease-causing variant with strong evidence
L.Path.Likely pathogenic — probable disease-causing variant
VUSVariant of uncertain significance — insufficient evidence
BenignBenign or likely benign — not disease-causing