Gene Panel Gallery — GaiaLab Landmark Analyses

11 panels shown

Oncology ✓ High Evidence

Hereditary Breast & Ovarian Cancer

Germline HR+/HER2− TNBC risk Stage II–III

BRCA1 BRCA2 PALB2 RAD51C

📈 Top pathway Homologous recombination repair Reactome/KEGG

⚖ Evidence strength —

💊 Drug signals —

Checking trials…

Olaparib · FDA ✓ Talazoparib · FDA ✓ Niraparib · FDA ✓ Veliparib · Ph3

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Oncology ✓ High Evidence

RAS/RAF Colorectal Cancer

Somatic mCRC BRAF V600E MSS

KRAS NRAS BRAF PIK3CA

📈 Top pathway MAPK/ERK signaling Reactome/KEGG

⚖ Evidence strength —

💊 Drug signals —

Checking trials…

Encorafenib · FDA ✓ Cetuximab · FDA ✓ Sotorasib · KRAS Adagrasib · KRAS

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Oncology ✓ High Evidence

NSCLC Precision Oncology

Somatic Stage IIIB–IV Adenocarcinoma TKI-naive

EGFR ALK MET ROS1

📈 Top pathway EGFR-PI3K-mTOR axis Reactome/KEGG

⚖ Evidence strength —

💊 Drug signals —

Checking trials…

Osimertinib · FDA ✓ Alectinib · FDA ✓ Crizotinib · FDA ✓ Capmatinib · MET

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Oncology ✓ High Evidence

Pan-Cancer Tumor Suppression

Somatic · LOF Pan-cancer TP53 hotspot CDK4/6-driven

TP53 MDM2 CDKN2A RB1

📈 Top pathway p53 signaling / cell cycle arrest Reactome/KEGG

⚖ Evidence strength —

💊 Drug signals —

Checking trials…

Palbociclib · FDA ✓ Abemaciclib · FDA ✓ AMG-232 · MDM2 APR-246 · TP53

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Oncology ✓ High Evidence

Glioblastoma Multiforme

IDH-wildtype Primary GBM MGMT methylated WHO Grade 4

IDH1 IDH2 EGFR PTEN MGMT

📈 Top pathway PI3K/AKT/mTOR Reactome/KEGG

⚖ Evidence strength —

💊 Drug signals —

Checking trials…

Temozolomide · FDA ✓ Ivosidenib · IDH1 Bevacizumab · FDA ✓ Vorasidenib · IDH

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Oncology ✓ High Evidence

Acute Myeloid Leukemia

FLT3-ITD+ De novo AML Intermediate risk ELN 2022

FLT3 NPM1 DNMT3A IDH1

📈 Top pathway FLT3 / epigenetic dysregulation Reactome/KEGG

⚖ Evidence strength —

💊 Drug signals —

Checking trials…

Midostaurin · FLT3 FDA ✓ Gilteritinib · FLT3 FDA ✓ Ivosidenib · IDH1 FDA ✓ Azacitidine · Epi

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Neurology ⚠ Medium Evidence

Alzheimer's Disease

Late-onset APOE ε4 Amyloid+/Tau+ MCI→AD

APP APOE PSEN1 PSEN2 TREM2

📈 Top pathway Amyloid precursor processing Reactome/KEGG

⚖ Evidence strength —

💊 Drug signals —

Checking trials…

Lecanemab · FDA ✓ Donepezil · FDA ✓ Memantine · FDA ✓ Donanemab · Ph3

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Neurology ⚠ Medium Evidence

Parkinson's Disease

LRRK2 G2019S Sporadic PD α-syn aggregation Early-onset

SNCA LRRK2 PARK7 PINK1 PRKN

📈 Top pathway Mitochondrial quality control Reactome/KEGG

⚖ Evidence strength —

💊 Drug signals —

Checking trials…

Levodopa · FDA ✓ Rasagiline · FDA ✓ Prasinezumab · SNCA Ambroxol · GBA

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Oncology ✓ High Evidence

PI3K/AKT Pathway Cancers

PIK3CA H1047R Breast · Endometrial HR+ / HER2− mTORC1-driven

PIK3CA PTEN AKT1 MTOR

📈 Top pathway PI3K-AKT-mTOR signaling Reactome/KEGG

⚖ Evidence strength —

💊 Drug signals —

Checking trials…

Alpelisib · PIK3CA FDA ✓ Everolimus · mTOR FDA ✓ Capivasertib · AKT FDA ✓ Idelalisib · PI3K

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Metabolism ⚠ Medium Evidence

Type 2 Diabetes

GWAS-derived T2D · non-obese β-cell dysfunction Insulin resistance

TCF7L2 PPARG KCNJ11 SLC30A8

📈 Top pathway Insulin secretion / glucose homeostasis Reactome/KEGG

⚖ Evidence strength —

💊 Drug signals —

Checking trials…

Pioglitazone · PPARG FDA ✓ Metformin · SoC Empagliflozin · FDA ✓ Semaglutide · FDA ✓

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Oncology ✓ High Evidence

Colorectal Cancer — MSI-High

MSI-High dMMR Immunotherapy resp. Lynch syndrome

MLH1 MSH2 MSH6 PMS2 POLE

📈 Top pathway Mismatch repair deficiency / neoantigen burden Reactome/KEGG

⚖ Evidence strength —

💊 Drug signals —

Checking trials…

Pembrolizumab · FDA ✓ MSI-H Nivolumab · FDA ✓ Ipilimumab · combo FDA ✓ Dostarlimab · dMMR

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